Samsung isn't the first company to break into the phablet space, but those of you waiting for a (more than) worthy successor to devices like the Dell Streak 5 won't have much longer to wait. AT&T has just announced that their pocket-busting Galaxy Note will be hitting their sales channels on February 19, complete with a $300 price tag.Source: http://feedproxy.google.com/~r/Techcrunch/~3/IKwMytt2D8c/
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ScienceDaily (Jan. 30, 2012) ? When it comes to addiction, sex matters. A new brain imaging study by Yale School of Medicine researchers suggests stress robustly activates areas of the brain associated with craving in cocaine-dependent women, while drug cues activate similar brain regions in cocaine-dependent men.? The study, expected to be published online Jan. 31 in the American Journal of Psychiatry, suggests men and women with cocaine dependence might benefit more from different treatment options.
"There are differences in treatment outcomes for people with addictions who experience stress-induced drug cravings and those whose cravings are induced by drug cues," said Marc Potenza, professor of psychiatry, child study, and neurobiology and first author of the study. "It is important to understand the biologic mechanisms that underlie these cravings."
The researchers conducted functional magnetic resonance imaging scans of 30 cocaine-dependent individuals and 36 control subjects who were recreational drinkers. While undergoing brain scans, researchers then presented subjects with personalized cues (situations or events) the participants had indicated were personally stressful and other cues involving cocaine or alcohol.
As expected, cocaine-dependent individuals showed greater activation in broad regions of the brain linked to addiction and motivation than the control subjects. Patterns of activation between the groups, however, differed markedly in men and women when presented with stress or drug cues.
Potenza said the findings suggest that women with cocaine dependence might benefit from stress-reduction therapies that specifically target these cravings. Men, on the other hand, might derive more benefit from elements of cognitive behavioral therapy or 12-step programs based on the principles of Alcoholics Anonymous.
The senior author of the paper is Rajita Sinha of Yale. Other Yale authors are Kwang-ik Adam Hong, Cheryl M. Lacadie, Robert K. Fulbright, and Keri L. Tuit.
The study was supported by the Yale Stress Center, Women's Health Research at Yale, the Connecticut Department of Mental Health and Addiction Services, and grants from the National Institutes of Health and its Office of Research on Women's Health.
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The above story is reprinted from materials provided by Yale University. The original article was written by Bill Hathaway.
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Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/zGnBhgVBXhA/120130131511.htm
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NEW DELHI ? Two states in northern India with 20 million voters are choosing state assemblies in elections testing the popularity of the national government's ruling Congress party.
Paramilitary troops patrolled thousands of polling stations for the votes Monday in Punjab and Uttarakhand states.
In Punjab, often called India's bread basket, the Congress is trying to wrest power from a coalition including the main opposition Bharatiya Janata Party. Results of the elections are not expected until March 6.
The biggest test for Congress will be elections starting next week in India's biggest state, Uttar Pradesh, which are viewed as a make or break moment for Congress Party leader Rahul Gandhi.
Gandhi has launched an intense campaign to dislodge the state's ruling party.
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The GOP presidential race has been one of the most turbulent in recent memory, with just about everyone having their 15 minutes at the top of the heap. Now that some candidates have dropped out, endorsements are starting to trickle in. So just who is doing the endorsing so far, and which candidates are receiving the nods?
Herman Cain
Herman Cain has thrown his full support behind Newt Gingrich, according to The Ticket. It is unclear how much effect this endorsement will have on Gingrich's campaign in Florida, but it might not be lost on female voters that he and Cain have reportedly a rocky history with respect to women in their personal lives.
Bob Dole
Not only has Bob Dole endorsed Mitt Romney, he had some pretty harsh words for Gingrich in recent days, according to the National Journal. Dole is reported as saying "Hardly anyone who served with Newt in Congress has endorsed him and that fact speaks for itself." It might not be the most resounding endorsement for Romney, but it is a small blow to the Gingrich campaign.
George H.W. Bush
Former President Bush hasn't hit the campaign trail for Mitt Romney, but he has said Romney has his vote, according to CBS News. This is probably not surprising given the history between Gingrich and Bush after the president raised taxes despite a pledge not to. Still, it can't feel great to have the former leader of your party state publicly that he does not want to vote for you.
Rick Perry
Rick Perry announced after ending his campaign that he would be endorse Gingrich, according to The Ticket. Perry attempted to deflect the importance of concerns about Gingrich's infidelity by stating, "Newt is not perfect, but who among us is?" Picking up some of Perry's evangelical voters would be a coup for Gingrich in this race.
Celebrity Endorsements
* Joe Rogan. Ron Paul's campaign is reporting the host of "Fear Factor" and frequent UFC commentator has offered his endorsement.
* Jon Voight. Angelina Jolie's famous father has put his support in Romney, according to ABC News.
* Chuck Norris. Walker Texas Ranger has announced he will be backing Gingrich, according to the Daily Beast.
* Jim Bob Duggar. The famous father of 19 children has stated that his family is backing Rick Santorum.
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VIENNA?? Senior United Nations nuclear inspectors headed to Tehran on Saturday to press Iranian officials to address suspicions that the Islamic state is seeking atomic weapons.
The U.N. International Atomic Energy Agency hopes Iran, which has indicated readiness to discuss the issue for the first time since 2008, will end years of stonewalling on intelligence pointing to an intention to develop nuclear arms technology.
"We are trying ... to resolve all the outstanding issues with Iran, in particular we hope that Iran will engage with us on our concerns regarding the possible military dimensions of Iran's nuclear program," IAEA Deputy Director General Herman Nackaerts told reporters as he prepared to depart from Vienna airport.
But Western diplomats, who have often accused Iran of using such offers of dialogue as a stalling tactic while it presses ahead with its nuclear program, say they doubt Tehran will show the kind of concrete cooperation the IAEA wants.
They say Iran may offer limited concessions and transparency in an attempt to ease intensifying international pressure on the country, a major oil producer, but that this is unlikely to amount to the full cooperation that is required.
The outcome could determine whether Iran will face further international isolation, or whether there are prospects for resuming wider talks between Tehran and the major powers on the nuclear dispute that has sparked fears of war.
The United States and its allies suspect the program has military aims but Tehran says is for peaceful electricity generation.
"The chances of the IAEA's success may depend on how badly Iran wants to avoid harder sanctions," said nuclear expert Mark Hibbs of the Carnegie Endowment for International Peace.
Story: Israel senses bluffing in Iran's retaliation threatsRemarks by Supreme Leader Ayatollah Ali Khamenei's top adviser on international affairs on Saturday suggested Iran was not in the mood for concessions.
"Iran's stance towards its nuclear issue has not changed in term of fundamentals and principles," Ali Akbar Velayati said, according to the ISNA news agency.
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"One important principle is that Iran would not relinquish or withdraw from its peaceful nuclear activities."
The six-member IAEA team of senior officials and experts, headed by Nackaerts, was due to arrive in Tehran early on Sunday.
The three-day visit comes at a time of soaring tension between Iran and the West. The IAEA issued a report in November with details of suspected research and development activities in Iran relevant to nuclear weapons.
The West has seized on the report to ratchet up sanctions aimed at Iran's lifeblood oil exports. Iran hit back on Friday warning it may halt oil exports to Europe next week.
'Appearing to cooperate'
The IAEA team is expected to seek explanations to the issues raised in the report, including information that Iran appears to have worked on a nuclear weapon design, and demand access to sites, officials and documents relevant to the agency's probe.
The IAEA says Iran, which has rejected the allegations as forged and baseless, has not engaged with the agency in a substantive way on these issues since August 2008 and that it keeps receiving intelligence data adding to its concerns.
"There were a huge number of questions raised by the November report. They will be seeking to answer those questions, and it's incumbent on Iran to be supportive," U.S. State Department spokeswoman Victoria Nuland said this week.
IAEA Director General Yukiya Amano has called on Iran to show a "constructive spirit" in the meeting and Iran has said it is willing to discuss "any issues" of interest to the U.N. agency, including the military-linked concerns.
Video: Exclusive: tensions flare near crucial oil chokepointIran's Press TV state television said on its website the IAEA visit was aimed at bolstering cooperation between the two sides "by resolving ambiguities," language Tehran has also used in the past.
The English-language station cited Iran's envoy to the IAEA, Ali Asghar Soltanieh, as saying the main objective was to "thwart plots by enemies who are leveling unfounded allegations" against Iran and to prove its nuclear transparency.
Hibbs said Amano would want to see a "significant step" from Iran, for example by agreeing to more intrusive IAEA inspections or by explaining issues related to the weapons suspicions.
"I'm not very optimistic," Hibbs said. "Iran's track record is of appearing to cooperate whenever they are threatened by penalties."
Meanwhile, European oil companies that are owed oil by Iran could lose out if Iran imposes a ban on crude exports to the EU next week, a measure currently before the Iranian parliament, the head of Iran's state oil company said Saturday.
"Generally, the parties to incur damage from the EU's recent decision will be European companies with pending contracts with Iran," Ahmad Qalebani, head of the National Iranian Oil Co., told the ISNA news agency.
"The European companies will have to abide by the provisions of the buyback contracts," he said. "If they act otherwise, they will be the parties to incur the relevant losses and will subject the repatriation of their capital to problems."
The EU banned imports of oil from Iran Monday and imposed a number of other economic sanctions, joining the United States in a new round of measures aimed at deflecting Tehran's nuclear development program.
Copyright 2012 Thomson Reuters. Click for restrictions.
Source: http://www.msnbc.msn.com/id/46174915/ns/world_news-mideast_n_africa/
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![[ Back to EurekAlert! ]](http://www.eurekalert.org/images/back2e.gif){kind=small}
Public release date: 27-Jan-2012
Share ] Contact: Wang Shengdian
sdwang@moon.ibp.ac.cn
0086-106-488-8493
Science in China Press
Cancer is one of the most common causes of death in humans. The conventional cancer therapies include surgery, radiotherapy, chemotherapy, and targeting therapies, which are intended to directly destroy and eliminate tumor cells. These treatments often fail, resulting in tumor metastasis and recurrence. Therefore, there is a critical need for novel cancer therapies. In recent years, an increasing number of studies have revealed that immune responses play a critical role in conventional cancer therapies. Replication-selective oncolytic viruses are a rapidly expanding therapeutic platform for cancer. Professor Wang Shengdian and his group from the Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, have studied tumor immunity for several years, with a team focusing on oncolytic adenovirus. In this work, entitled "CD8+ T cell response mediates the therapeutic effects of oncolytic adenovirus in an immunocompetent mouse model", published in Chinese Science Bulletin 2012, Vol. 57(1), this team has demonstrated that the host anti-tumor immune responses, especially the CD8+ T cell responses, play a critical role in the therapeutic effects of oncolytic adenovirus. These studies might shed light on novel cancer therapies.
Researchers have identified several oncolytic viruses such as poliovirus, adenovirus, vesicular stomatitis virus, reovirus, and vaccinia virus, which can selectively infect or replicate in cancer cells, but spare normal cells. Among these, adenovirus has been the most commonly used oncolytic virus in the last decade, because of its efficacy, safety, and ease of manipulation. When administered to tumors, oncolytic adenovirus infects and kills cancer cells as a result of the normal viral life cycle, by replicating in cells and releasing progeny viruses. However, adenoviral infection is immunogenic and can induce strong anti-viral immune responses, which accelerate the clearance of virus and limit the therapeutic effects on cancer. Some studies have shown that suppressing the immune system could enhance the efficacy of oncolytic vectors. On the other hand, recent preclinical and clinical studies have suggested that the immune response plays an important role in mediating the antitumor efficacy. Therefore, the influence of immune responses on oncolytic therapy is complex. Because of the species specificity of adenoviral replication, it was widely assumed that adenoviral replication would not occur in mouse tumors. Consequently, oncolytic adenoviral vectors have been commonly evaluated in immunodeficient mouse-human tumor xenograft models, which do not accurately reflect what happens in humans treated with oncolytic adenovirus. A team led by Professor Yaohe Wang from the Center for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, previously screened a panel of mouse tumor cell lines and identified two cell linesCMT 93 (a murine rectal cancer cell line) and CMT64 (a murine non-small-cell lung cancer cell line) with significant permissibility for adenoviral gene expression, cytopathic effects, and/or replication.
In this work, the team lead by Professor Wang Shengdian evaluated the roles of immune components in oncolytic adenoviral therapy with a murine tumor by subcutaneously inoculating CMT 93 cells into syngeneic C57BL/6 mice. They found that CD8+ T cells, but not CD4+ T cells or natural killer cells, are critical mediators of the antitumor efficacy of oncolytic adenovirus by deletion of the corresponding cell subsets with specific antibodies. Intratumoral injection of adenovirus serotype 5 (Ad5) could induce intensive infiltration of CD8+ T cells into the tumor, and increase tumor-specific interferon-? production and cytotoxic T lymphocyte activity. The anti-tumor T cell responses induced by Ad5 therapy produced long-term tumor-specific memory immune responses that protected the cured mice well from tumor rechallenge. This anti-tumor immune memory is thought to play a major role in preventing tumor relapse. For larger tumors, Ad5 therapy alone controls tumor growth only transiently. However, Ad5 therapy followed by treatment with agonistic anti-4-1BB (cluster differentiation 137, CD137) antibody, a potent enhancer of the specific CD8+ T cell response, resulted in complete rejection of all transplanted tumors, demonstrating that promotion of T cell responses against tumors could enhance the therapeutic effects of oncolytic adenovirus.
In summary, this study provides insight into the antitumor mechanisms of oncolytic adenovirus, in addition to their direct oncolytic effect. Meanwhile, this study proposes a new and more effective therapeutic regime for cancer treatment using a combination therapy of oncolytic adenovirus and immunotherapy.
###
See the article: YANG Y J, LI X Z, WANG Y H, WANG S D. CD8+ T cell response mediates the therapeutic effects of oncolytic adenovirus in an immunocompetent mouse model. Chinese Science Bulletin 2012 Vol. 57(1): 48-53.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 27-Jan-2012 Share ] Contact: Wang Shengdian
sdwang@moon.ibp.ac.cn
0086-106-488-8493
Science in China Press
Cancer is one of the most common causes of death in humans. The conventional cancer therapies include surgery, radiotherapy, chemotherapy, and targeting therapies, which are intended to directly destroy and eliminate tumor cells. These treatments often fail, resulting in tumor metastasis and recurrence. Therefore, there is a critical need for novel cancer therapies. In recent years, an increasing number of studies have revealed that immune responses play a critical role in conventional cancer therapies. Replication-selective oncolytic viruses are a rapidly expanding therapeutic platform for cancer. Professor Wang Shengdian and his group from the Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, have studied tumor immunity for several years, with a team focusing on oncolytic adenovirus. In this work, entitled "CD8+ T cell response mediates the therapeutic effects of oncolytic adenovirus in an immunocompetent mouse model", published in Chinese Science Bulletin 2012, Vol. 57(1), this team has demonstrated that the host anti-tumor immune responses, especially the CD8+ T cell responses, play a critical role in the therapeutic effects of oncolytic adenovirus. These studies might shed light on novel cancer therapies.
Researchers have identified several oncolytic viruses such as poliovirus, adenovirus, vesicular stomatitis virus, reovirus, and vaccinia virus, which can selectively infect or replicate in cancer cells, but spare normal cells. Among these, adenovirus has been the most commonly used oncolytic virus in the last decade, because of its efficacy, safety, and ease of manipulation. When administered to tumors, oncolytic adenovirus infects and kills cancer cells as a result of the normal viral life cycle, by replicating in cells and releasing progeny viruses. However, adenoviral infection is immunogenic and can induce strong anti-viral immune responses, which accelerate the clearance of virus and limit the therapeutic effects on cancer. Some studies have shown that suppressing the immune system could enhance the efficacy of oncolytic vectors. On the other hand, recent preclinical and clinical studies have suggested that the immune response plays an important role in mediating the antitumor efficacy. Therefore, the influence of immune responses on oncolytic therapy is complex. Because of the species specificity of adenoviral replication, it was widely assumed that adenoviral replication would not occur in mouse tumors. Consequently, oncolytic adenoviral vectors have been commonly evaluated in immunodeficient mouse-human tumor xenograft models, which do not accurately reflect what happens in humans treated with oncolytic adenovirus. A team led by Professor Yaohe Wang from the Center for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, previously screened a panel of mouse tumor cell lines and identified two cell linesCMT 93 (a murine rectal cancer cell line) and CMT64 (a murine non-small-cell lung cancer cell line) with significant permissibility for adenoviral gene expression, cytopathic effects, and/or replication.
In this work, the team lead by Professor Wang Shengdian evaluated the roles of immune components in oncolytic adenoviral therapy with a murine tumor by subcutaneously inoculating CMT 93 cells into syngeneic C57BL/6 mice. They found that CD8+ T cells, but not CD4+ T cells or natural killer cells, are critical mediators of the antitumor efficacy of oncolytic adenovirus by deletion of the corresponding cell subsets with specific antibodies. Intratumoral injection of adenovirus serotype 5 (Ad5) could induce intensive infiltration of CD8+ T cells into the tumor, and increase tumor-specific interferon-? production and cytotoxic T lymphocyte activity. The anti-tumor T cell responses induced by Ad5 therapy produced long-term tumor-specific memory immune responses that protected the cured mice well from tumor rechallenge. This anti-tumor immune memory is thought to play a major role in preventing tumor relapse. For larger tumors, Ad5 therapy alone controls tumor growth only transiently. However, Ad5 therapy followed by treatment with agonistic anti-4-1BB (cluster differentiation 137, CD137) antibody, a potent enhancer of the specific CD8+ T cell response, resulted in complete rejection of all transplanted tumors, demonstrating that promotion of T cell responses against tumors could enhance the therapeutic effects of oncolytic adenovirus.
In summary, this study provides insight into the antitumor mechanisms of oncolytic adenovirus, in addition to their direct oncolytic effect. Meanwhile, this study proposes a new and more effective therapeutic regime for cancer treatment using a combination therapy of oncolytic adenovirus and immunotherapy.
###
See the article: YANG Y J, LI X Z, WANG Y H, WANG S D. CD8+ T cell response mediates the therapeutic effects of oncolytic adenovirus in an immunocompetent mouse model. Chinese Science Bulletin 2012 Vol. 57(1): 48-53.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-01/sicp-imo011712.php
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LONDON ? Chris Isaak is returning to the roots of rock 'n' roll and doing it old-school: All in one take.
The U.S. soul singer headed back to the original Sun Studios in Memphis to record a collection that includes cover versions of hits by Elvis Presley and Johnny Cash. The album, "Beyond the Sun," was released this week and Isaak will soon embark on a string of U.S. concert dates.
The 56-year-old, well known for his mesmerizing vocals on the now-classic 1989 hit "Wicked Game," says the decision to make the new album was easy.
"I just went 'I'll sing a bunch of those songs I like singing. I got a band, I'll just call them up and tell them to come over,'" he told the Associated Press in an interview in London.
To make it truly authentic, Isaak and his band recorded with no headphones, no separate takes, just everyone listening to each other and going with the flow.
"It scared the hell out of the band because they go, you know, 'If I screw up the guitar solo then everybody is going to look at me,'" Isaak said.
Sun Studios, the record label owned by Sam Phillips, launched the careers of some of the greatest U.S. singer/songwriters ? including Elvis, Cash, Jerry Lee Lewis and Roy Orbison.
Influenced by those big names while growing up as a child in California, Isaak delivers his interpretations of "Ring of Fire," "Great Balls of Fire," "Can't Help Falling In Love," "Oh, Pretty Woman," while also penning his own original songs.
The first single to be released is one of Isaak's own, "Live It Up."
Fortunately for the band, the old-school approach to recording meant they ended up producing more songs than they had bargained for. Even Isaak's manager was surprised at the speed of production.
"She goes '38 songs? You finished 38 songs?' I said 'Yeah.' She said 'Well, you have to mix all those, that's going to cost a fortune.' I said 'No, they're all done. We just did it all at one time in a room.'"
The singer says he's never missed a show and neither has his drummer Kenney Dale Johnson or his bass player Rowland Salley in the 27 years they've been playing together.
"I'm very proud of them," he said.
Before forging a career in music, Isaak tried his hand at many different occupations: roofing, truck-driving, being a bouncer and even a boxer. He claims he was "lousy" at all of them, it was only with music that he finally found a job he can do well.
"Singing is something that I'm always happy to do it and going in the studio I never felt any pressure. I just feel like I get to sing, you know. It's fun," he said.
While many musicians decry the strain of touring, Isaak says he's lucky to be able to travel the world doing what he loves.
"I come from a small town and I come from a background where we didn't have money to travel," he said. "I thought I'd have to join the military to get to Europe. So I'm thrilled to travel."
U.S. fans will get a chance to see Isaak in action starting in Austin, Texas, on Feb. 13 and ending in Napa, California, on April 27.
But, despite the stereotypes about rockers, don't expect him to be raising hell on tour.
"I liked the rock n' roll, I never wanted the drugs and I never saw the sex because ...nobody ever suggested anything wild to me!" he said. "I think I look too much like a cop."
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