Tuesday, January 31, 2012

$300 Samsung Galaxy Note Will Hit AT&T On February 19

attnoteSamsung isn't the first company to break into the phablet space, but those of you waiting for a (more than) worthy successor to devices like the Dell Streak 5 won't have much longer to wait. AT&T has just announced that their pocket-busting Galaxy Note will be hitting their sales channels on February 19, complete with a $300 price tag.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/IKwMytt2D8c/

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Addicts' cravings have different roots in men and women

ScienceDaily (Jan. 30, 2012) ? When it comes to addiction, sex matters. A new brain imaging study by Yale School of Medicine researchers suggests stress robustly activates areas of the brain associated with craving in cocaine-dependent women, while drug cues activate similar brain regions in cocaine-dependent men.? The study, expected to be published online Jan. 31 in the American Journal of Psychiatry, suggests men and women with cocaine dependence might benefit more from different treatment options.

"There are differences in treatment outcomes for people with addictions who experience stress-induced drug cravings and those whose cravings are induced by drug cues," said Marc Potenza, professor of psychiatry, child study, and neurobiology and first author of the study. "It is important to understand the biologic mechanisms that underlie these cravings."

The researchers conducted functional magnetic resonance imaging scans of 30 cocaine-dependent individuals and 36 control subjects who were recreational drinkers. While undergoing brain scans, researchers then presented subjects with personalized cues (situations or events) the participants had indicated were personally stressful and other cues involving cocaine or alcohol.

As expected, cocaine-dependent individuals showed greater activation in broad regions of the brain linked to addiction and motivation than the control subjects. Patterns of activation between the groups, however, differed markedly in men and women when presented with stress or drug cues.

Potenza said the findings suggest that women with cocaine dependence might benefit from stress-reduction therapies that specifically target these cravings. Men, on the other hand, might derive more benefit from elements of cognitive behavioral therapy or 12-step programs based on the principles of Alcoholics Anonymous.

The senior author of the paper is Rajita Sinha of Yale. Other Yale authors are Kwang-ik Adam Hong, Cheryl M. Lacadie, Robert K. Fulbright, and Keri L. Tuit.

The study was supported by the Yale Stress Center, Women's Health Research at Yale, the Connecticut Department of Mental Health and Addiction Services, and grants from the National Institutes of Health and its Office of Research on Women's Health.

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The above story is reprinted from materials provided by Yale University. The original article was written by Bill Hathaway.

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/zGnBhgVBXhA/120130131511.htm

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Monday, January 30, 2012

State assembly elections held in northern India (AP)

NEW DELHI ? Two states in northern India with 20 million voters are choosing state assemblies in elections testing the popularity of the national government's ruling Congress party.

Paramilitary troops patrolled thousands of polling stations for the votes Monday in Punjab and Uttarakhand states.

In Punjab, often called India's bread basket, the Congress is trying to wrest power from a coalition including the main opposition Bharatiya Janata Party. Results of the elections are not expected until March 6.

The biggest test for Congress will be elections starting next week in India's biggest state, Uttar Pradesh, which are viewed as a make or break moment for Congress Party leader Rahul Gandhi.

Gandhi has launched an intense campaign to dislodge the state's ruling party.

Source: http://us.rd.yahoo.com/dailynews/rss/asia/*http%3A//news.yahoo.com/s/ap/20120130/ap_on_re_as/as_india_elections

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Sunday, January 29, 2012

GOP Candidates Begin to Pick Up Endorsements (ContributorNetwork)

The GOP presidential race has been one of the most turbulent in recent memory, with just about everyone having their 15 minutes at the top of the heap. Now that some candidates have dropped out, endorsements are starting to trickle in. So just who is doing the endorsing so far, and which candidates are receiving the nods?

Herman Cain

Herman Cain has thrown his full support behind Newt Gingrich, according to The Ticket. It is unclear how much effect this endorsement will have on Gingrich's campaign in Florida, but it might not be lost on female voters that he and Cain have reportedly a rocky history with respect to women in their personal lives.

Bob Dole

Not only has Bob Dole endorsed Mitt Romney, he had some pretty harsh words for Gingrich in recent days, according to the National Journal. Dole is reported as saying "Hardly anyone who served with Newt in Congress has endorsed him and that fact speaks for itself." It might not be the most resounding endorsement for Romney, but it is a small blow to the Gingrich campaign.

George H.W. Bush

Former President Bush hasn't hit the campaign trail for Mitt Romney, but he has said Romney has his vote, according to CBS News. This is probably not surprising given the history between Gingrich and Bush after the president raised taxes despite a pledge not to. Still, it can't feel great to have the former leader of your party state publicly that he does not want to vote for you.

Rick Perry

Rick Perry announced after ending his campaign that he would be endorse Gingrich, according to The Ticket. Perry attempted to deflect the importance of concerns about Gingrich's infidelity by stating, "Newt is not perfect, but who among us is?" Picking up some of Perry's evangelical voters would be a coup for Gingrich in this race.

Celebrity Endorsements

* Joe Rogan. Ron Paul's campaign is reporting the host of "Fear Factor" and frequent UFC commentator has offered his endorsement.

* Jon Voight. Angelina Jolie's famous father has put his support in Romney, according to ABC News.

* Chuck Norris. Walker Texas Ranger has announced he will be backing Gingrich, according to the Daily Beast.

* Jim Bob Duggar. The famous father of 19 children has stated that his family is backing Rick Santorum.

Source: http://us.rd.yahoo.com/dailynews/rss/gop/*http%3A//news.yahoo.com/s/ac/20120129/pl_ac/10899515_gop_candidates_begin_to_pick_up_endorsements

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UN nuclear team heads to Iran

Senior United Nations nuclear inspectors headed to Tehran on Saturday to press Iranian officials to address suspicions that the Islamic state is seeking atomic weapons.

The U.N. International Atomic Energy Agency hopes Iran, which has indicated readiness to discuss the issue for the first time since 2008, will end years of stonewalling on intelligence pointing to an intention to develop nuclear arms technology.

"We are trying ... to resolve all the outstanding issues with Iran, in particular we hope that Iran will engage with us on our concerns regarding the possible military dimensions of Iran's nuclear program," IAEA Deputy Director General Herman Nackaerts told reporters as he prepared to depart from Vienna airport.

But Western diplomats, who have often accused Iran of using such offers of dialogue as a stalling tactic while it presses ahead with its nuclear program, say they doubt Tehran will show the kind of concrete cooperation the IAEA wants.

They say Iran may offer limited concessions and transparency in an attempt to ease intensifying international pressure on the country, a major oil producer, but that this is unlikely to amount to the full cooperation that is required.

The outcome could determine whether Iran will face further international isolation, or whether there are prospects for resuming wider talks between Tehran and the major powers on the nuclear dispute that has sparked fears of war.

The United States and its allies suspect the program has military aims but Tehran says is for peaceful electricity generation.

"The chances of the IAEA's success may depend on how badly Iran wants to avoid harder sanctions," said nuclear expert Mark Hibbs of the Carnegie Endowment for International Peace.

Story: Israel senses bluffing in Iran's retaliation threats

Remarks by Supreme Leader Ayatollah Ali Khamenei's top adviser on international affairs on Saturday suggested Iran was not in the mood for concessions.

"Iran's stance towards its nuclear issue has not changed in term of fundamentals and principles," Ali Akbar Velayati said, according to the ISNA news agency.

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"One important principle is that Iran would not relinquish or withdraw from its peaceful nuclear activities."

The six-member IAEA team of senior officials and experts, headed by Nackaerts, was due to arrive in Tehran early on Sunday.

The three-day visit comes at a time of soaring tension between Iran and the West. The IAEA issued a report in November with details of suspected research and development activities in Iran relevant to nuclear weapons.

The West has seized on the report to ratchet up sanctions aimed at Iran's lifeblood oil exports. Iran hit back on Friday warning it may halt oil exports to Europe next week.

'Appearing to cooperate'
The IAEA team is expected to seek explanations to the issues raised in the report, including information that Iran appears to have worked on a nuclear weapon design, and demand access to sites, officials and documents relevant to the agency's probe.

The IAEA says Iran, which has rejected the allegations as forged and baseless, has not engaged with the agency in a substantive way on these issues since August 2008 and that it keeps receiving intelligence data adding to its concerns.

"There were a huge number of questions raised by the November report. They will be seeking to answer those questions, and it's incumbent on Iran to be supportive," U.S. State Department spokeswoman Victoria Nuland said this week.

IAEA Director General Yukiya Amano has called on Iran to show a "constructive spirit" in the meeting and Iran has said it is willing to discuss "any issues" of interest to the U.N. agency, including the military-linked concerns.

Video: Exclusive: tensions flare near crucial oil chokepoint

Iran's Press TV state television said on its website the IAEA visit was aimed at bolstering cooperation between the two sides "by resolving ambiguities," language Tehran has also used in the past.

The English-language station cited Iran's envoy to the IAEA, Ali Asghar Soltanieh, as saying the main objective was to "thwart plots by enemies who are leveling unfounded allegations" against Iran and to prove its nuclear transparency.

Hibbs said Amano would want to see a "significant step" from Iran, for example by agreeing to more intrusive IAEA inspections or by explaining issues related to the weapons suspicions.

"I'm not very optimistic," Hibbs said. "Iran's track record is of appearing to cooperate whenever they are threatened by penalties."

Meanwhile, European oil companies that are owed oil by Iran could lose out if Iran imposes a ban on crude exports to the EU next week, a measure currently before the Iranian parliament, the head of Iran's state oil company said Saturday.

"Generally, the parties to incur damage from the EU's recent decision will be European companies with pending contracts with Iran," Ahmad Qalebani, head of the National Iranian Oil Co., told the ISNA news agency.

"The European companies will have to abide by the provisions of the buyback contracts," he said. "If they act otherwise, they will be the parties to incur the relevant losses and will subject the repatriation of their capital to problems."

The EU banned imports of oil from Iran Monday and imposed a number of other economic sanctions, joining the United States in a new round of measures aimed at deflecting Tehran's nuclear development program.

Copyright 2012 Thomson Reuters. Click for restrictions.

Source: http://www.msnbc.msn.com/id/46174915/ns/world_news-mideast_n_africa/

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Saturday, January 28, 2012

Immunological mechanisms of oncolytic adenoviral therapy

Immunological mechanisms of oncolytic adenoviral therapy [ Back to EurekAlert! ] Public release date: 27-Jan-2012
[ | E-mail | Share Share ]

Contact: Wang Shengdian
sdwang@moon.ibp.ac.cn
0086-106-488-8493
Science in China Press

Cancer is one of the most common causes of death in humans. The conventional cancer therapies include surgery, radiotherapy, chemotherapy, and targeting therapies, which are intended to directly destroy and eliminate tumor cells. These treatments often fail, resulting in tumor metastasis and recurrence. Therefore, there is a critical need for novel cancer therapies. In recent years, an increasing number of studies have revealed that immune responses play a critical role in conventional cancer therapies. Replication-selective oncolytic viruses are a rapidly expanding therapeutic platform for cancer. Professor Wang Shengdian and his group from the Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, have studied tumor immunity for several years, with a team focusing on oncolytic adenovirus. In this work, entitled "CD8+ T cell response mediates the therapeutic effects of oncolytic adenovirus in an immunocompetent mouse model", published in Chinese Science Bulletin 2012, Vol. 57(1), this team has demonstrated that the host anti-tumor immune responses, especially the CD8+ T cell responses, play a critical role in the therapeutic effects of oncolytic adenovirus. These studies might shed light on novel cancer therapies.

Researchers have identified several oncolytic viruses such as poliovirus, adenovirus, vesicular stomatitis virus, reovirus, and vaccinia virus, which can selectively infect or replicate in cancer cells, but spare normal cells. Among these, adenovirus has been the most commonly used oncolytic virus in the last decade, because of its efficacy, safety, and ease of manipulation. When administered to tumors, oncolytic adenovirus infects and kills cancer cells as a result of the normal viral life cycle, by replicating in cells and releasing progeny viruses. However, adenoviral infection is immunogenic and can induce strong anti-viral immune responses, which accelerate the clearance of virus and limit the therapeutic effects on cancer. Some studies have shown that suppressing the immune system could enhance the efficacy of oncolytic vectors. On the other hand, recent preclinical and clinical studies have suggested that the immune response plays an important role in mediating the antitumor efficacy. Therefore, the influence of immune responses on oncolytic therapy is complex. Because of the species specificity of adenoviral replication, it was widely assumed that adenoviral replication would not occur in mouse tumors. Consequently, oncolytic adenoviral vectors have been commonly evaluated in immunodeficient mouse-human tumor xenograft models, which do not accurately reflect what happens in humans treated with oncolytic adenovirus. A team led by Professor Yaohe Wang from the Center for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, previously screened a panel of mouse tumor cell lines and identified two cell linesCMT 93 (a murine rectal cancer cell line) and CMT64 (a murine non-small-cell lung cancer cell line) with significant permissibility for adenoviral gene expression, cytopathic effects, and/or replication.

In this work, the team lead by Professor Wang Shengdian evaluated the roles of immune components in oncolytic adenoviral therapy with a murine tumor by subcutaneously inoculating CMT 93 cells into syngeneic C57BL/6 mice. They found that CD8+ T cells, but not CD4+ T cells or natural killer cells, are critical mediators of the antitumor efficacy of oncolytic adenovirus by deletion of the corresponding cell subsets with specific antibodies. Intratumoral injection of adenovirus serotype 5 (Ad5) could induce intensive infiltration of CD8+ T cells into the tumor, and increase tumor-specific interferon-? production and cytotoxic T lymphocyte activity. The anti-tumor T cell responses induced by Ad5 therapy produced long-term tumor-specific memory immune responses that protected the cured mice well from tumor rechallenge. This anti-tumor immune memory is thought to play a major role in preventing tumor relapse. For larger tumors, Ad5 therapy alone controls tumor growth only transiently. However, Ad5 therapy followed by treatment with agonistic anti-4-1BB (cluster differentiation 137, CD137) antibody, a potent enhancer of the specific CD8+ T cell response, resulted in complete rejection of all transplanted tumors, demonstrating that promotion of T cell responses against tumors could enhance the therapeutic effects of oncolytic adenovirus.

In summary, this study provides insight into the antitumor mechanisms of oncolytic adenovirus, in addition to their direct oncolytic effect. Meanwhile, this study proposes a new and more effective therapeutic regime for cancer treatment using a combination therapy of oncolytic adenovirus and immunotherapy.

###

See the article: YANG Y J, LI X Z, WANG Y H, WANG S D. CD8+ T cell response mediates the therapeutic effects of oncolytic adenovirus in an immunocompetent mouse model. Chinese Science Bulletin 2012 Vol. 57(1): 48-53.



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Immunological mechanisms of oncolytic adenoviral therapy [ Back to EurekAlert! ] Public release date: 27-Jan-2012
[ | E-mail | Share Share ]

Contact: Wang Shengdian
sdwang@moon.ibp.ac.cn
0086-106-488-8493
Science in China Press

Cancer is one of the most common causes of death in humans. The conventional cancer therapies include surgery, radiotherapy, chemotherapy, and targeting therapies, which are intended to directly destroy and eliminate tumor cells. These treatments often fail, resulting in tumor metastasis and recurrence. Therefore, there is a critical need for novel cancer therapies. In recent years, an increasing number of studies have revealed that immune responses play a critical role in conventional cancer therapies. Replication-selective oncolytic viruses are a rapidly expanding therapeutic platform for cancer. Professor Wang Shengdian and his group from the Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, have studied tumor immunity for several years, with a team focusing on oncolytic adenovirus. In this work, entitled "CD8+ T cell response mediates the therapeutic effects of oncolytic adenovirus in an immunocompetent mouse model", published in Chinese Science Bulletin 2012, Vol. 57(1), this team has demonstrated that the host anti-tumor immune responses, especially the CD8+ T cell responses, play a critical role in the therapeutic effects of oncolytic adenovirus. These studies might shed light on novel cancer therapies.

Researchers have identified several oncolytic viruses such as poliovirus, adenovirus, vesicular stomatitis virus, reovirus, and vaccinia virus, which can selectively infect or replicate in cancer cells, but spare normal cells. Among these, adenovirus has been the most commonly used oncolytic virus in the last decade, because of its efficacy, safety, and ease of manipulation. When administered to tumors, oncolytic adenovirus infects and kills cancer cells as a result of the normal viral life cycle, by replicating in cells and releasing progeny viruses. However, adenoviral infection is immunogenic and can induce strong anti-viral immune responses, which accelerate the clearance of virus and limit the therapeutic effects on cancer. Some studies have shown that suppressing the immune system could enhance the efficacy of oncolytic vectors. On the other hand, recent preclinical and clinical studies have suggested that the immune response plays an important role in mediating the antitumor efficacy. Therefore, the influence of immune responses on oncolytic therapy is complex. Because of the species specificity of adenoviral replication, it was widely assumed that adenoviral replication would not occur in mouse tumors. Consequently, oncolytic adenoviral vectors have been commonly evaluated in immunodeficient mouse-human tumor xenograft models, which do not accurately reflect what happens in humans treated with oncolytic adenovirus. A team led by Professor Yaohe Wang from the Center for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, previously screened a panel of mouse tumor cell lines and identified two cell linesCMT 93 (a murine rectal cancer cell line) and CMT64 (a murine non-small-cell lung cancer cell line) with significant permissibility for adenoviral gene expression, cytopathic effects, and/or replication.

In this work, the team lead by Professor Wang Shengdian evaluated the roles of immune components in oncolytic adenoviral therapy with a murine tumor by subcutaneously inoculating CMT 93 cells into syngeneic C57BL/6 mice. They found that CD8+ T cells, but not CD4+ T cells or natural killer cells, are critical mediators of the antitumor efficacy of oncolytic adenovirus by deletion of the corresponding cell subsets with specific antibodies. Intratumoral injection of adenovirus serotype 5 (Ad5) could induce intensive infiltration of CD8+ T cells into the tumor, and increase tumor-specific interferon-? production and cytotoxic T lymphocyte activity. The anti-tumor T cell responses induced by Ad5 therapy produced long-term tumor-specific memory immune responses that protected the cured mice well from tumor rechallenge. This anti-tumor immune memory is thought to play a major role in preventing tumor relapse. For larger tumors, Ad5 therapy alone controls tumor growth only transiently. However, Ad5 therapy followed by treatment with agonistic anti-4-1BB (cluster differentiation 137, CD137) antibody, a potent enhancer of the specific CD8+ T cell response, resulted in complete rejection of all transplanted tumors, demonstrating that promotion of T cell responses against tumors could enhance the therapeutic effects of oncolytic adenovirus.

In summary, this study provides insight into the antitumor mechanisms of oncolytic adenovirus, in addition to their direct oncolytic effect. Meanwhile, this study proposes a new and more effective therapeutic regime for cancer treatment using a combination therapy of oncolytic adenovirus and immunotherapy.

###

See the article: YANG Y J, LI X Z, WANG Y H, WANG S D. CD8+ T cell response mediates the therapeutic effects of oncolytic adenovirus in an immunocompetent mouse model. Chinese Science Bulletin 2012 Vol. 57(1): 48-53.



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-01/sicp-imo011712.php

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AP Interview: Chris Isaak makes Memphis album (AP)

LONDON ? Chris Isaak is returning to the roots of rock 'n' roll and doing it old-school: All in one take.

The U.S. soul singer headed back to the original Sun Studios in Memphis to record a collection that includes cover versions of hits by Elvis Presley and Johnny Cash. The album, "Beyond the Sun," was released this week and Isaak will soon embark on a string of U.S. concert dates.

The 56-year-old, well known for his mesmerizing vocals on the now-classic 1989 hit "Wicked Game," says the decision to make the new album was easy.

"I just went 'I'll sing a bunch of those songs I like singing. I got a band, I'll just call them up and tell them to come over,'" he told the Associated Press in an interview in London.

To make it truly authentic, Isaak and his band recorded with no headphones, no separate takes, just everyone listening to each other and going with the flow.

"It scared the hell out of the band because they go, you know, 'If I screw up the guitar solo then everybody is going to look at me,'" Isaak said.

Sun Studios, the record label owned by Sam Phillips, launched the careers of some of the greatest U.S. singer/songwriters ? including Elvis, Cash, Jerry Lee Lewis and Roy Orbison.

Influenced by those big names while growing up as a child in California, Isaak delivers his interpretations of "Ring of Fire," "Great Balls of Fire," "Can't Help Falling In Love," "Oh, Pretty Woman," while also penning his own original songs.

The first single to be released is one of Isaak's own, "Live It Up."

Fortunately for the band, the old-school approach to recording meant they ended up producing more songs than they had bargained for. Even Isaak's manager was surprised at the speed of production.

"She goes '38 songs? You finished 38 songs?' I said 'Yeah.' She said 'Well, you have to mix all those, that's going to cost a fortune.' I said 'No, they're all done. We just did it all at one time in a room.'"

The singer says he's never missed a show and neither has his drummer Kenney Dale Johnson or his bass player Rowland Salley in the 27 years they've been playing together.

"I'm very proud of them," he said.

Before forging a career in music, Isaak tried his hand at many different occupations: roofing, truck-driving, being a bouncer and even a boxer. He claims he was "lousy" at all of them, it was only with music that he finally found a job he can do well.

"Singing is something that I'm always happy to do it and going in the studio I never felt any pressure. I just feel like I get to sing, you know. It's fun," he said.

While many musicians decry the strain of touring, Isaak says he's lucky to be able to travel the world doing what he loves.

"I come from a small town and I come from a background where we didn't have money to travel," he said. "I thought I'd have to join the military to get to Europe. So I'm thrilled to travel."

U.S. fans will get a chance to see Isaak in action starting in Austin, Texas, on Feb. 13 and ending in Napa, California, on April 27.

But, despite the stereotypes about rockers, don't expect him to be raising hell on tour.

"I liked the rock n' roll, I never wanted the drugs and I never saw the sex because ...nobody ever suggested anything wild to me!" he said. "I think I look too much like a cop."

Source: http://us.rd.yahoo.com/dailynews/rss/music/*http%3A//news.yahoo.com/s/ap/20120127/ap_en_mu/eu_people_chris_isaak

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Friday, January 27, 2012

LMFAO Joining Madonna At Super Bowl?

Will.i.am says party rockers will perform with Queen of Pop for halftime show on February 5.
By Gil Kaufman


LMFAO
Photo: Steven Lawton/ FilmMagic

It's a good thing the Super Bowl provides its halftime performer with the biggest platform in television, because according to the latest rumors Madonna is going to need a seriously massive stage to hold all her guests at the February 5 game.

Following reports that Nicki Minaj and M.I.A. as well as "The Voice" coach Cee Lo Green may make appearances comes news that LMFAO could be called off the bench also.

A year after his group, the on-hiatus Black Eyed Peas, played the big game,
 will.i.am told English radio station Capital FM that his party-rocking homies will be in the mix. "I'm going to the Super Bowl this year to see my group LMFAO perform with Madonna," he said. "Check that out, Will.i.am Music Group is pretty freaking two for two! One year the Super Bowl, the next year another group part of the Super Bowl in collaboration with Madonna. That's still happening."

According to sources, Madonna asked Green to perform with her at the showdown in Indianapolis between the New York Giants and the New England Patriots, which is traditionally the most-watched TV event of the year. TheInsider.com reports that he's been flying to New York to rehearse with the pop icon. The sources add that he will contribute his signature flair to some of her classic tunes.

The pairing would make sense given that the new season of "The Voice" premieres right after the Super Bowl next month. MTV News caught up with the Queen of Pop at her "W.E." premiere earlier this week in New York, and the singer only had one tease about the Super Bowl gig. "I am not saying 'Yes,' and "I am not saying yes and I am not saying no," she replied when asked whether Minaj and M.I.A. will join her onstage, adding, "Pom-poms. That's all I can tell you."

As if the pom-poms and all the alleged guests aren't enough, the halftime show will be "imagined" by trippy Canadian circus troupe Cirque du Soleil and Madonna's longtime choreographer and creative director Jamie King. According to reports, the set list could include Madonna's new single, "Give Me All Your Luvin," as well as such classics as "Ray of Light," "Vogue" and "Music."

In addition to her Super Bowl performance, Madonna's fans are awaiting the release of her next studio album, M.D.N.A., out later this year.

Related Artists

Source: http://www.mtv.com/news/articles/1678014/lmfao-madonna-super-bowl-halftime.jhtml

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Delta 4Q profit soars on higher fares, demand (AP)

MINNEAPOLIS ? Delta Air Lines' fourth-quarter net income rose sharply, as higher fares offset a bigger fuel bill.

Like other carriers, Delta was able to raises fares by cutting the amount of flying it did at the end of last year. The money it made flying a passenger a single mile rose 12 percent.

The company's fourth-quarter net income rose to $425 million, or 50 cents per share, compared with $19 million, or 2 cents, a year earlier, when it was hit with charges from early debt repayment and consolidation of airport operations.

Revenue rose 8 percent to $8.4 billion in the latest quarter, helping counter a 5-percent rise in fuel expenses on its mainline operations. Other costs were flat.

Excluding one-time gains and losses, Delta earned 45 cents per share, beating the 37 cents expected by analysts polled by FactSet.

Delta's 2011 profit totaled $854 million, 44 percent higher than in 2010. Revenue rose 11 percent to $35 billion. It has now turned a profit two years in a row.

Delta's strategy of reducing flying to match demand will continue. The carrier said Wednesday that it will cut flying capacity 3 percent to 5 percent during the first quarter of 2012.

Shares of Atlanta-based Delta Air Lines Inc. rose 47 cents, or 5 percent, to $9.85 in premarket trading.

___

AP Airlines Writer Samantha Bomkamp in New York contributed to this report.

Source: http://us.rd.yahoo.com/dailynews/rss/earnings/*http%3A//news.yahoo.com/s/ap/20120125/ap_on_bi_ge/us_earns_delta

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Thursday, January 26, 2012

Online car insurance For Kid Drivers ? Tips on how to Save Money ...

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Unlike some other state codes, the Minnesota motor insurance regulations suggest that the driver really need uninsured driver coverage in addition to underinsured driver (UM/UIM) insurance plan. Differences might be $1,000 and up! So, the great thing to achieve? Be knowledgeable and cautious when you find yourself on the street. There really are others that like find out initial information how they were seeking will contact websites auto insurance corporation because now they wish to find through the quality details that is included and the policy they will mean to activate on the vehicle. When periods are firm, and corners end up being cut, reasonable as so that you can why obligation coverage makes slashed. When the marring your automobile exceeds the beauty of the automobile the motor insurance claims adjuster can certainly declare your truck a write-off. When paying for insurance for one Classic Auto many people reckon that if many purchase ?agreed benefit insurance? the difficulty is more than. Although the individual has chosen the upper protection even though they and then the other said drivers really are operating the automobile, if permissive end user were make use of the vehicle and turn in an accident the insurance corporation would default your coverage provided towards the coverage stated in your insuring legal contract. If you wish to get the most beneficial deal, then you ought to find mud cheap motor insurance quotes in addition to do your special comparison. On other hand, if you locate a company that could be willing we could a quote with no need for you to definitely provide a great deal information, you may have to offer more data prefer a more real quotation. Collision insurance plan covers the price of getting marring your own personal car set. Many other relevant facts are your current driving the past and newly released claims. Fact: Insurance companies are certainly competitive in concert. Especially within a time connected with recession. PIP insures medical purchases, and perhaps lost wages together with other damages. PIP might be sometimes referred to as ?no-fault? insurance plan, because your statutes who enacted this are referred to as no-fault protocols.

Source: http://www.fcsafekids.org/2012/01/24/online-car-insurance-for-kid-drivers-tips-on-how-to-save-money-on-the-cover/

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Wednesday, January 25, 2012

Brad Pitt On Oscar Nods: 'Pancakes For Everyone'

Actor tells Today Show he's 'ecstatic' about 'Moneyball' and 'Tree of Life' nominations.
By Jocelyn Vena


Brad Pitt in "Moneyball"
Photo: Sony Pictures

On Tuesday morning (January 24), "Moneyball" star Brad Pitt heard his name called several times when the Oscar nominations were announced. Shortly after, the actor called in to "The Today Show" to open up about being recognized not only for his acting skills, but also his work getting the baseball film off the ground as a producer.

"We're ecstatic over here. It means so much considering this film was just dead on the rocks two years ago," he said from L.A. "It took a lot of people to get it to the screen. It's a great honor. I'm really happy."

Pitt got a couple nods thanks to his producer credit on the best picture nominee and his work in the leading role. His co-star Jonah Hill also got some love with a supporting actor nomination. "I'm so happy for Jonah Hill," he gushed. "I can't tell you." Another film he recently starred in, "Tree of Life," also got some Academy love, making Pitt's morning an especially good one. "I'm doubly happy that 'Tree of Life' made it in there," he said. "We thought we were all but forgotten; just excited for [director and nominee] Terry Malick."

Pitt will once again face off against his pal and Golden Globe winner George Clooney for Actor in a Leading Role for his work in "The Descendants," but he's not too worried about it. "I'm sure we'll be exchanging many good words later," he said. "It's more fun to have a friend there and no one does it better than George. I say give him all the trophies, and when you run out of trophies, make some new ones and give him those too. " When asked what prize he wants to win most come Oscars night, he played it cool saying, "I could not pick. I'm just so happy that both these films have been recognized. 'Tree of Life' was just as difficult to get made and it's gonna be pancakes for everyone this morning."

Did "Moneyball" deserve all the Academy love? Let us know what you think in the comments.

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Source: http://www.mtv.com/news/articles/1677784/oscar-nominations-brad-pitt.jhtml

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Britney Spears? conservatorship is set to be dropped as she prepares to wed for the third time

The Toxic hitmaker’s father Jamie was handed control of her personal and financial affairs following her much-publicised breakdown in 2008. Spears has since got her life on track – she’s released her seventh studio album, Femme Fatale, and toured the world to promote the release. Her longtime boyfriend and former agent Jason Trawick marked the [...]

Source: http://www.celebritymound.com/britney-spears-conservatorship-is-set-to-be-dropped-as-she-prepares-to-wed-for-the-third-time/?utm_source=rss&utm_medium=rss&utm_campaign=britney-spears-conservatorship-is-set-to-be-dropped-as-she-prepares-to-wed-for-the-third-time

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Saturday, January 21, 2012

Pro-fighter Gina Carano goes "Haywire" in movie debut (omg!)

Mixed Martial Arts (MMA) fighter and actress Gina Carano poses for a portrait while promoting the film "Haywire" in Beverly Hills, California, January 7, 2012. REUTERS/Danny Moloshok

LOS ANGELES (Reuters) - Retired female mixed martial arts fighter Gina Carano may be a household name to those in the sporting world, but the 29-year old beauty is now broadening her horizons to include acting.

Carano, a pioneer in the world of female competitive fighting, makes her big screen debut in Steven Soderbergh's action thriller "Haywire," in U.S. theaters on Friday. She plays a framed government agent who must prove her innocence and find out who betrayed her, all the while warding off assassins.

Carano sat down with Reuters to talk about her first film and making the transition from fighting to acting.

Q: You've never starred in a film before. What was that like?

A: "I feel like I went to Film School 101 on 'Haywire' because I never experienced anything like this. I've never read lines with an actor and I got Michael Fassbender for my very first actor in Dublin. I was sitting there in awe. I was like, 'Okay, this is what's he's doing, so I just gotta keep up.' He actually became a mentor to me for the majority of the movie."

Q: Any take-away moments for you during this first experience?

A: "Every single day in this movie is ingrained in my heart. You have certain firsts in your life but this whole movie was a first -- my first time acting, my first day of filming in Dublin with Michael Fassbender. Steven Soderbergh is my first director. It was my first time in Barcelona, my first time in New Mexico."

Q: The film was designed to showcase your strengths as a fighter. That must have made your experience much less daunting.

A: "Any day I was physical, I was really happy. That's where my confidence came from - from the running to the fight scenes. I think that's why Steven kept me active in the film, so I wouldn't get into my head too much."

Q: What was the most challenging thing?

A: "Reading lines and acting, but that soon became an every day thing...But I learned how vulnerable a person has to be, how open they have to be. You have to let yourself go and be ridiculous and let go whatever walls you have up. That's not incredibly easy for me."

Q: What do you consider yourself now - an actor or a fighter?

A: "I'm definitely between worlds. The fighting world is like, 'Wow, she left us,' or 'She was one of us, we respect her for that.' And the acting world is like, 'Who is this? Who is this stranger?' (laughs) So it's like starting over."

Q: So you want to continue with acting?

A: "Fighting is always my first love and my passion. With acting, I got to express myself in a different way...I didn't have to hurt anybody or get hurt doing it, but I could still be physical. I would love to do that again."

Q: So what's next for you then? Are producers and studios lining up to meet with you?

A: "I think a lot of people have been reserved on this. They don't know what to expect yet. I have little projects here and there that are on hold because people have been waiting for the film to come out first. Of course I've got a little anxiety, like, 'What's next?'"

Q: You've paved the way for so many young female fighters and now you're kicking butt on the big screen. Do you feel like a role model?

A: "If you're inspired, God bless you and keep being inspired by as many people you can...Because if you can see it in me, you can see it in yourself. But don't build anybody up too high because they'll just let you down. I've done so many things wrong in my life and I've done so many things right, but I'm real and you can talk to me and if I inspire you, I'm glad. But be you."

Q: How does a middle child of three sisters end up a fighter?

A: "I was the boy my dad never had - the darker one with dark eyes, dark hair and big bones. So I played that role my whole life. I got in street fights because I was never good at talking."

Q: So even as a kid you fought?

A: "I definitely did. I had a lot of street fights growing up in Las Vegas. Not ones that I instigated, but I would not back down. My mom and dad both told me: punch a bully in the nose and they'll go away. You don't have to be pushed around. That's something I hope I can access more as I get older"

Q: Punching bullies in noses?

A: "No, life. Punch life in the nose if it starts pushing you around. You gotta face it. You can't run from it."

(Editing By Jill Serjeant)

Source: http://us.rd.yahoo.com/dailynews/rss/entertainment/*http%3A//us.rd.yahoo.com/dailynews/external/omg_rss/rss_omg_en/news_pro_fighter_gina_carano_goes_haywire_movie_debut210042276/44221696/*http%3A//omg.yahoo.com/news/pro-fighter-gina-carano-goes-haywire-movie-debut-210042276.html

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Friday, January 20, 2012

Hamas bans singing competition in Gaza (AP)

JERUSALEM ? Organizers of the Palestinian version of "American Idol" said Thursday the Gaza Strip's Hamas rulers have banned residents from participating in the popular reality show.

The organizers said Hamas told them the program is "indecent," in what appears to be a new attempt by the fundamentalist militant Muslim group to crack down on behavior it sees as contrary to its conservative interpretation of Islam.

In the past, Hamas has banned women from riding on the backs of motorbikes, women from smoking water pipes, and men from working in hair salons ? saying such practices were immodest. Not all bans are imposed uniformly.

The ban on competing in New Star came around the same time that Hamas police beat up members of Gaza's tiny Shiite minority while they tried to hold a religious ceremony.

Alaa al-Abed, the chief producer of the "New Star" program, said the edict would prevent Gaza's 12 contestants from competing in the upcoming second round of the competition Thursday night. It will be broadcast next month. He said he was informed of the decision last Saturday.

"This is more serious than Hamas just killing fun in Gaza ? they are limiting the freedoms of the people, according to their whims," al-Abed said.

There was no official comment from Hamas.

In the past, Gaza contestants have competed via video conference due to travel restrictions imposed on Gaza residents by Egypt and Israel. This year Hamas banned that form of participation as well.

New Star is broadcast on satellite television in the West Bank, Gaza Strip and Israel. A panel of judges rate performers signing pop songs, and viewers vote for their favorites.Now in its third year, it is a popular show with Palestinians.

In past years, contestants have included young women crooning in sleeveless dresses ? a look that is unthinkable in conservative Gaza ? while others wore Muslim headscarves. All of this year's Gaza contestants were men.

Hamas permits male barbershop style singing groups that do not use musical instruments and sing of the glory of Islam and to fighting Israel. Young, prepubescent girls also perform in their own singing groups, but teenage girls and women are never seen singing in public. Many devout Muslims believe singing by women is provocative.

Al-Abed said he was told by the head of Gaza's government press office, Hassan Abu Hashish, that the local singers could not compete because the program was not in compliance with the territory's culture and it was not morally acceptable.

Abu Hashish could not be reached for comment. But a statement released Wednesday by his office accused New Star's owners, the Palestinian news agency Maan, of incitement in a lengthy series of grievances about the company. Maan is based in the more liberal West Bank and receives generous funding from European donor nations.

"It has harmed (our) culture and traditions," Abu Hashish's statement read. They "show all of Gaza ... as if its youth search for singing programs."

Al-Abed said that Gazans were able to participate last year without any limitations. He urged Hamas to change its policy.

"People want to participate. We tried to make (Abu-Hashish) understand ? even if only 5 percent of people want to sing, if they want to participate ? why prevent them?"

Organizers say they hope that New Star can help unite the Palestinians, who have been divided between rival governments in the West Bank and Gaza since Hamas violently took control of Gaza in 2007. The Palestinians hope to turn the two territories, located on opposite sides of Israel, into an independent state.

Source: http://us.rd.yahoo.com/dailynews/rss/mideast/*http%3A//news.yahoo.com/s/ap/20120119/ap_on_re_mi_ea/ml_palestinians_singing_ban

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Thursday, January 19, 2012

Samsung commits to improve smartphone battery life in 2012


Sure, we all love having the latest and greatest smartphone from the likes of Samsung, but the power consumption driven by larger displays, LTE, and more use is making it increasingly harder to get through the day. Samsung's vice president of product innovation, Kevin Packingham, said in an interview with CNET that Korea's darling has set the lofty goal that smartphones coming out this year last an entire day under average to moderately heavy use. Samsung's plans include beefing up batteries, but it also intends to look at improving energy efficiency by tweaking the various radios -- LTE, WiFi -- to make them a little less greedy. Motorola has already seemingly caught this wave with the RAZR MAXX -- a slightly chubbier Motorola RAZR -- which is essentially the same set as the RAZR but with enough juice so you can use it instead of spending your day looking for an outlet to charge it. Unfortunately, things could get sticky as the definition of "moderately heavy use" is a pretty tough thing to pin down. Would you put up with a huskier phone to get you through the day or is a slim set more important? Feel free to chime in with your comments below.

Samsung commits to improve smartphone battery life in 2012 originally appeared on Engadget on Tue, 17 Jan 2012 12:57:00 EDT. Please see our terms for use of feeds.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/tu1-lzE2gTQ/

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Wednesday, January 18, 2012

Car bomb kills at least 8 in Iraq's Mosul: hospital (Reuters)

MOSUL, Iraq (Reuters) ? A car bomb exploded inside a residential complex housing displaced Shi'ite Muslims in the Iraqi city of Mosul on Monday, killing at least eight people and wounding four, hospital and police sources said.

The bombing was the latest in a series of attacks on Shi'ite pilgrims and other targets since a political crisis erupted a month ago in Iraq's fragile power-sharing government, split among Shi'ite, Sunni Muslim and Kurdish blocs.

"The hospital received eight bodies including four women, three children and a man and another four wounded," said Laith Habbaba, manager of the Hamdaniya Hospital in Mosul.

Police confirmed the number of casualties.

On Saturday, a suicide bomber disguised as a policeman killed at least 53 people and wounded scores in an attack on Shi'ite pilgrims at a checkpoint in the southern city of Basra.

Political tensions in Iraq have been high since December when Shi'ite Prime Minister Nuri al-Maliki's government ordered the arrest of a Sunni vice president, touching off a crisis that has many fearing a relapse into sectarian conflict.

Mosul, 390 km (240 miles) north of Baghdad, was once an al Qaeda stronghold, and witnessed some of the fiercest fighting during the war that followed the 2003 U.S.-led invasion.

(Reporting by Jamal al-Badrani; Writing by Suadad al-Salhy; Editing by Patrick Markey and Mark Heinrich)

Source: http://us.rd.yahoo.com/dailynews/rss/world/*http%3A//news.yahoo.com/s/nm/20120116/wl_nm/us_iraq_violence

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Tuesday, January 17, 2012

Ben Flajnik on Shawntel Newton: Hot Girl, Bad Timing!


Wow.

That's what many viewers are saying after last night's Bachelor episode in which Shawntel Newton, from Brad Womack's season, entered the game unexpectedly.

Ben Flajnik, the star of this season, was caught at the center of the "$h!t storm" last night, and reacted similarly by the big twist designed to rile up the women.

In a new blog post, he explains why he sent Shawntel packing:

Handsome Ben FlajnikShawntel Newton

"So I have heard from everyone that makes this show happen that this was truly the craziest cocktail party and rose ceremony in Bachelor history," he writes.

"Having only seen one other season, I would have to agree. Wow. Nothing in my life would have ever prepared me for the $h!tstorm that happened that night."

"After watching, I didn't realize that the women were so mean to Shawntel and I was a bit taken aback," Ben reflects in the understatement of the year. "I mean I knew it was a bold move on Shawntel's part, but some of the women took it a bit too far."

"Shawntel and I had chatted a few times in between seasons and I thought she was an interesting, beautiful woman. She was right to assume there was a connection."

"There was, but the timing was wrong. So, you can imagine how surprised I was when she showed up to the cocktail party unannounced."

"I knew if I kept Shawntel around I would lose all the credibility I had built with these women and it wouldn't be easy to dig myself out of that hole."

"Let's put it this way - if Shawntel had started the journey with the rest of the women it might have been different. But I was already so happy with the group of women I had. I wasn't about to jeopardize the rest of my experience in trying to find love."

"I do want to thank Shawntel though for coming. She gave up a lot to try this and I really respect her for it."

Source: http://www.thehollywoodgossip.com/2012/01/ben-flajnik-on-shawntel-newton-hot-girl-bad-timing/

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Friday, January 13, 2012

Let’s Have Rush Limbaugh Moderate a GOP Debate

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Tuesday, January 10, 2012

Eyes On Sony's Latest Glasses-Free 3-D TV: They're Getting There! [3dTv]

"Glasses-free 3-D TV" sounds crazy because, well, that would look like real life, right? The newest Sony incarnation of the mythical television feels closer than ever—almost like Sony might actually Lasek our 3-D TV experience one day. More »


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Iran welcomes US rescue of boat from pirates

Iran's government on Saturday welcomed the U.S. Navy's rescue of 13 Iranian fishermen held by pirates, calling it a positive humanitarian gesture.

U.S. officials announced Friday that the fishermen had been rescued by a U.S. Navy destroyer on Thursday, more than 40 days after their boat was commandeered by suspected Somali pirates in the northern Arabian Sea. The rescue came just days after Tehran warned the U.S. to keep the same group of warships out of the Persian Gulf in a reflection of Iran's fear that American warships could try to enforce an embargo against Iranian oil exports.

"The rescue of Iranian sailors by American forces is considered a humanitarian gesture and we welcome this behavior," Foreign Ministry spokesman Ramin Mehmanparast was quoted as saying by state TV's Al-Alam Arabic channel.

Iran's hard-line Fars news agency had a different take, calling the rescue operation a Hollywood dramatization of a routine event.

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The Fars report noted that attacks by Somali pirates in the region are common and said that Iran's navy has itself freed many mariners held by pirates in recent years without seeking to highly publicize it.

Amid escalating tension with Iran over its nuclear program, the Obama administration reveled in delivering Friday's announcement and highlighted the fact that the rescuing ships were the same ones Iran's army chief had just said were no longer welcome in the Persian Gulf.

US Navy rescues 13 Iranian seamen from pirates

"Basically, rescuing trading and fishing boats from the hands of pirates in the Arabian Sea and the Gulf of Aden is considered a completely normal issue," Fars said. "A U.S. helicopter filming the rescue operation from the first minute makes it look like a Hollywood drama with specific locations and actors. It shows the Americans tried to publicize it through the media and present the American warship as a savior."

The semiofficial Fars news agency is considered close to Iran's powerful Revolutionary Guard military force.

Fars reported in April that Iranian naval commandos had driven off pirates attempting to hijack a supertanker off Pakistan's southwestern coast.

"Iran's navy has rescued various foreign ships from the hands of pirates ... but never publicized that," it said.

Tough talk
Naval forces from several countries patrol shipping lanes in the region in pursuit of Somali pirates. The pirates, who are after huge ransoms, have dramatically expanded their range in recent years and targeted some of the largest vessels to take to the seas, including oil supertankers.

The episode occurred after a week of tough talk from Iranian leaders, including the statement that American vessels were no longer welcome in the Gulf. Iran also warned it could block the Strait of Hormuz, the strategic waterway through which a sixth of the world's oil flows to market.

US: Iran 'flailing' for friends in Latin America

The Iranian threats, which were brushed aside by the Obama administration, were in response to strong economic sanctions against Iran over its disputed nuclear enrichment program. A week ago, President Barack Obama signed into law new sanctions targeting Iran's central bank and its ability to sell petroleum abroad.

At the same time, Iran has sought to project its naval power, carrying out 10 days of military drills at sea near the strategic Strait of Hormuz.

On Saturday, Iran's Revolutionary Guard began new war games near the Afghan border, according to the Guard's website, sepahnews.com.

Mohammad Pakpoor, commander of the Guard's ground force, said the maneuvers began outside Khaf, an eastern town near the border. He said the war games were aimed at strengthening Iran's borders and increasing the combat readiness of the Guard's ground force.

Iran is also planning new military exercises near the Hormuz Strait next month.

Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://www.msnbc.msn.com/id/45910331/ns/world_news-mideast_n_africa/

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Little-known oil and gas regulator election imminent

My first gig at a daily newspaper was covering cops for the Abilene Reporter-News, and my first story was about a car collision with a train at a railroad crossing. Someone must have mentioned that perhaps the warning lights didn?t flash because the next thing you know, I was in a frenzy of ?investigation? to figure out if the state had dropped the ball in regulating the safety of crossings.

My first call? The Texas Railroad Commission, which, I found out, has nothing to do with railroads.

It regulates the oil and gas industry.

Today, I can count myself among the relative minority of Texans who recognize the TRC doesn?t rule the railroads.

Nonetheless, the three people who run the agency ? which most recently, also included the regulation of hydraulic fracturing fluids ? are elected officials. Two of those three spots are open seats this year.

Quick ? can you name one of the three people on the commission today?

I talked to Mark Jones, chair of the political science department at Rice University?

?The Texas Railroad Commission can have a real impact on public policy in Texas, but you?d be hard-pressed to find two or three people who have any idea what they do,? he said. ?Almost nobody knows it exists, and even fewer know what it actually does.?

As Jones explained it, when voters don?t know the candidates, they often fall back on party affiliation. Consequently, a seat on the Texas Railroad Commission is generally won in the Republican primary, which is currently scheduled to occur on April 3, 2012.

In 2011, the Texas Senate passed a bill to reduce the number of commissioners from three to one and to rename it to the Texas Oil and Gas Commission, but it went up in flames before the session ended.

Deon covers energy and law for the Houston Business Journal.

Source: http://feedproxy.google.com/~r/bizj_houston/~3/bVX72EVe4BQ/little-known-oil-and-gas-regulator.html

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